Dr. Jounghyun Helen Lee

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  • I am a materials engineer focusing on biomedical problems. I have extensive experience in microfabrication, lithography, microscopy, spectroscopy, and most importantly microfluidics for biological applications, in addition to cellular molecular biology techniques. My research interests are on (1) development and commercialization of microscale tools for biomedical science of limited resources (such as rare cells, patient samples etc.); (2) micro- and nano-scale fabrication of biological systems for cell-cell and cell-matrix signaling and for engineering of immune systems; (3)tissue formation and their complex interactions with biomaterials, drugs, cytokines, and pathogens in physiologically relevant microenvironments. I also am highly motivated in communicating with non-technical audiences and mentoring students.

  • Research Scientist, Biomedical Engineering (MPS), Columbia University 2018 – 2022

    Adjunct Professor and Research Scientist, Biomedical Engineering (ImmunoEngineering), Columbia University 2015 - 2018

    Postdoctoral Research Fellow, Biomedical Engineering (Lance Kam Lab), Columbia University 2011- 2014

    Postdoctoral Research Associate, Materials Science & Engineering, Stevens Institute of Technology 2010

    Graduate Research Assistant, Materials S&E, Stevens Institute of Technology (Hoboken, NJ) 2004 – 2010

    Research Engineer, SAMSUNG NEC MOBILE DISPLAY Co. Ltd., R&D Center (Kiheung, Korea) 2001 – 2003

    Researcher, SAMSUNG SDI Co. Ltd., Research Center (Suwon, Korea) 1997 – 2000

  • J. H. Lee, Z. Chen, S. He, J. Zhou, A. Tsai, G. Truskey, and Kam W. Leong, “Emulating Early Atherosclerosis in a Vascular Micro physiological System Using Branched Tissue-Engineered Blood Vessels.” Adv. Biol. 5:2000428 (2021).

    N. Nataraj, A. P. Dang, L. Kam, and J. H. Lee*, “Ex vivo Induction of Regulatory T cells from Conventional CD4 + T cells is Sensitive to Substrate Rigidity,” J. Biomed. Mater. Res. A 106:3001 (2018).

    J. H. Lee and L. Kam. The Immune Synapse. “Revealing the Role of Microscale Architecture in Immune Synapse Function Through Surface Micropatterning,” Humana Press, New York, NY (ISBN 978-1-4939-6881-7).

    J. H. Lee, M.L. Dustin, and L.C. Kam, “A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays” Integratvie Biology 7:1442 (2015)

    K. Bashour, J. Tsai, K. Shen, J. H. Lee, E. Sun, M. C. Milone, M. L. Dustin, and L. C. Kam, “Crosstalk between CD3 and CD28 is spatially modulated by protein lateral mobility” Molecular and Cellular Biology 34:955 (2014)

    J. H. Lee, Y. Gu, H. Wang, and W.Y. Lee, “Microfluidic 3D Bone Tissue Model for High-Throughput Evaluation of Wound-Healing and Infection-Preventing Biomaterials” Biomaterials 33:999 (2012)

    J. H. Lee, H. Wang, J.B. Kaplan, and W.Y. Lee, “Microfluidic Approach to Create 3D Tissue Models for Biofilm-Related Infection of Orthopaedic Implants” Tissue Engineering, 17:39 (2011)

    J. H. Lee, J.B. Kaplan, and Woo Lee, “Microfluidic devices for studying growth and detachment of Staphylococcus epidermidis biofilms” Biomedical Microdevices, 10(4):489 (2008)